Substrate binding to cytochromes P450
نویسندگان
چکیده
منابع مشابه
Ensemble modeling of substrate binding to cytochromes P450: analysis of catalytic differences between CYP1A orthologs.
A novel application of modeling and docking approaches involving ensembles of homology models is used to understand structural bases underlying subtle catalytic differences between related cytochromes P450 (CYPs). Mammalian CYP1A1s and fish CYP1As are orthologous enzymes with similar substrate preferences. With some substrates (3,3',4,4'-tetrachlorobiphenyl, TCB) oxidation rates differ by order...
متن کاملThe 2002 Bernard B. Brodie Award lecture: deciphering substrate recognition by drug-metabolizing cytochromes P450.
It is an honor to be the recipient of the 2002 Bernard B. Brodie Award in Drug Metabolism from the American Society for Pharmacology and Experimental Therapeutics. In receiving this award, I join a distinguished group of honorees (Coon, 1981; Jerina, 1983; Mannering, 1986; Nebert, 1988; Levin, 1990; Kalow, 1990; Ziegler, 1991; Gillette, 1991; Guengerich, 1993; Ortiz de Montellano, 1995; Lu, 199...
متن کاملWhichCyp: prediction of cytochromes P450 inhibition
SUMMARY In this work we present WhichCyp, a tool for prediction of which cytochromes P450 isoforms (among 1A2, 2C9, 2C19, 2D6 and 3A4) a given molecule is likely to inhibit. The models are built from experimental high-throughput data using support vector machines and molecular signatures. AVAILABILITY The WhichCyp server is freely available for use on the web at http://drug.ku.dk/whichcyp, wh...
متن کاملHuman cytochromes P450 in health and disease.
There are 18 mammalian cytochrome P450 (CYP) families, which encode 57 genes in the human genome. CYP2, CYP3 and CYP4 families contain far more genes than the other 15 families; these three families are also the ones that are dramatically larger in rodent genomes. Most (if not all) genes in the CYP1, CYP2, CYP3 and CYP4 families encode enzymes involved in eicosanoid metabolism and are inducible...
متن کاملCytochromes P450 in the bioactivation of chemicals.
The initial view that the cytochrome P450 enzyme system functions simply in the deactivation of xenobiotics is anachronistic on the face of mounting evidence that this system can also transform many innocuous chemicals to toxic products. However, not all xenobiotic-metabolising cytochrome P450 subfamilies show the same propensity in the bioactivation of chemicals. For example, the CYP2C, 2B and...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Analytical and Bioanalytical Chemistry
سال: 2008
ISSN: 1618-2642,1618-2650
DOI: 10.1007/s00216-008-2244-0